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Application progress of lymphography in oncology

Yang YU, Jibin LIU, Lixue YIN

Frontiers of Medicine 2009, Volume 3, Issue 1,   Pages 13-19 doi: 10.1007/s11684-009-0016-7

Abstract: Lymphography is often used for the diagnosis of lymphatic metastasis in oncology.Determination of lymphatic metastasis is extremely important for accurate cancer staging, which may directly

Keywords： lymphography     lymphatic metastasis     sentinel lymph node biopsy    

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Correlation of Twist upregulation and senescence bypass during the progression and metastasis of cervical

Tian Wang, Yan Li, Abidan Tuerhanjiang, Wenwen Wang, Zhangying Wu, Ming Yuan, Shixuan Wang

Frontiers of Medicine 2014, Volume 8, Issue 1,   Pages 106-112 doi: 10.1007/s11684-014-0307-5

Abstract:

Cervical carcinoma is associated with high propensity for local invasion and lymph node metastasisHowever, the molecular alterations that drive progression and metastasis of cervical cancer remain unclearThis gene also exhibits a positive function in regulating invasion and metastasis.The strong positive expressions of Twist in the SCC groups with or without lymph node metastasis wereOur results suggested that the expression of Twist increased during the progression and metastasis of

Keywords： cervical cancer     senescence     Twist     CBX3     lymph node metastasis    

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Clinical significance of para-aortic lymph node dissection and prognosis in ovarian cancer

Xianxian Li, Hui Xing, Lin Li, Yanli Huang, Min Zhou, Qiong Liu, Xiaomin Qin, Min He

Frontiers of Medicine 2014, Volume 8, Issue 1,   Pages 96-100 doi: 10.1007/s11684-014-0316-4

Abstract:

Lymph node metastasis has an important effect on prognosis of patients with ovarian cancer.Nineteen cases of lymph node metastasis were found in group A, among whom seven cases were positive forIn group B, 13 cases were positive for lymph node metastasis.Our study suggested that the metastatic rate of lymph node is 40.0%.Lymph node metastasis was significantly correlated with FIGO stage, tumor differentiation, and histological

Keywords： ovarian cancer     para-aortic lymph node     pelvic lymph node    

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Adjuvant chemotherapy versus adjuvant concurrent chemoradiotherapy after radical surgery for early-stage cervical cancer: a randomized, non-inferiority, multicenter trial

Frontiers of Medicine 2023, Volume 17, Issue 1,   Pages 93-104 doi: 10.1007/s11684-021-0892-z

Abstract: We conducted a prospective study to assess the non-inferiority of adjuvant chemotherapy alone versus adjuvant concurrent chemoradiotherapy (CCRT) as an alternative strategy for patients with early-stage (FIGO 2009 stage IB–IIA) cervical cancer having risk factors after surgery. The condition was assessed in terms of prognosis, adverse effects, and quality of life. This randomized trial involved nine centers across China. Eligible patients were randomized to receive adjuvant chemotherapy or CCRT after surgery. The primary end-point was progression-free survival (PFS). From December 2012 to December 2014, 337 patients were subjected to randomization. Final analysis included 329 patients, including 165 in the adjuvant chemotherapy group and 164 in the adjuvant CCRT group. The median follow-up was 72.1 months. The three-year PFS rates were both 91.9%, and the five-year OS was 90.6% versus 90.0% in adjuvant chemotherapy and CCRT groups, respectively. No significant differences were observed in the PFS or OS between groups. The adjusted HR for PFS was 0.854 (95% confidence interval 0.415–1.757; P = 0.667) favoring adjuvant chemotherapy, excluding the predefined non-inferiority boundary of 1.9. The chemotherapy group showed a tendency toward good quality of life. In comparison with post-operative adjuvant CCRT, adjuvant chemotherapy treatment showed non-inferior efficacy in patients with early-stage cervical cancer having pathological risk factors. Adjuvant chemotherapy alone is a favorable alternative post-operative treatment.

Keywords： chemotherapy     cervical cancer     lymph node metastasis     concurrent chemoradiotherapy     quality of life    

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The value of ultrasound elastography in differential diagnosis of superficial lymph nodes

Yanrong ZHANG phD , Qing LV MD , Mingxing XIE MD , Feixiang XIANG phD , Chengfa LU BM , Tianwei YAN BM , Wei LI BM , Hui XU BM , Yan HUANG BM , Yehua YIN BM ,

Frontiers of Medicine 2009, Volume 3, Issue 3,   Pages 368-374 doi: 10.1007/s11684-009-0063-0

Abstract: evaluated the value of ultrasound elastography in differentiating the benign and malignant superficial lymphA total of 112 subjects, including 82 patients with enlarged lymph nodes and 30 healthy volunteers, wereThe elasticity of the lymph nodes was quantitatively measured and defined as stiffness value.The stiffness values of two indeterminate benign lymph nodes, the elastrographic findings of which wereThe elastographic findings of 10 malignant lymph nodes were also classified as pattern 2 or 3.

Keywords： ultrasound elastography     lymph node     power Doppler sonography    

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Superenhancers activate the autophagy-related genes Beclin1 and LC3B to drive metastasis and drug resistance

Frontiers of Medicine 2022, Volume 16, Issue 6,   Pages 883-895 doi: 10.1007/s11684-022-0919-0

Abstract: Metastasis and drug resistance are the leading causes of poor prognosis in patients with osteosarcomaIdentifying the relevant factors that drive metastasis and drug resistance is the key to improving theKnockdown of Beclin1 and LC3B reduced invasion, metastasis, and proliferation in metastatic osteosarcoma and in vivo studies also demonstrated that inhibiting by 3-MA inhibited cell growth and metastasisautophagy-related genes were activated by SEs and that the inhibition of SEs by JQ-1 decreased the metastasis

Keywords： osteosarcoma     autophagy     metastasis     drug resistance     Beclin1     LC3B    

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Osteopontin is a promoter for hepatocellular carcinoma metastasis: a summary of 10 years of studies

Lunxiu Qin

Frontiers of Medicine 2014, Volume 8, Issue 1,   Pages 24-32 doi: 10.1007/s11684-014-0312-8

Abstract:

In this review, we summarize the novel findings from our series of studies on the leading metastasis-relatedgene expression profiling study, OPN was identified as one of the leading genes associated with the metastasisWe focused on OPN to evaluate its prognostic values and important roles in HCC metastasis.both in vitro and in vivoinvestigations, we found that OPN has an important role in metastasisand tumor growth of HCC and is an attractive potential therapeutic target for combating HCC metastasis

Keywords： osteopontin (OPN)     hepatocellular carcinoma     metastasis     prognosis     therapeutic target     biomarker     genetic    

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Bone metastasis of hepatocellular carcinoma: facts and hopes from clinical and translational perspectives

Frontiers of Medicine 2022, Volume 16, Issue 4,   Pages 551-573 doi: 10.1007/s11684-022-0928-z

Abstract: Patients with hepatocellular carcinoma (HCC) and bone metastasis (BM) suffer from greatly reduced life

Keywords： HCC     bone     osteotropism     clinical     basic researches     advances    

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Spatial embedded reinforcement of 20-node block element for analysis PC bridges

LONG Peiheng, DU Xianting, CHEN Weizhen

Frontiers of Structural and Civil Engineering 2008, Volume 2, Issue 3,   Pages 274-280 doi: 10.1007/s11709-008-0039-1

Abstract: It is an effective approach that the no-node loads are diverted from the tendons to the adjacent concrete

Keywords： arithmetic analysis     calculation     prestressed reinforcement     mechanical     arbitrary    

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Effect of atorvastatin on tumor growth and metastasis in a breast cancer cell xenograft model and its

Liu LIU MD, PhD, Yaogui NING MM, Chen CHEN MD, Daowen WANG MD, PhD,

Frontiers of Medicine 2009, Volume 3, Issue 4,   Pages 443-446 doi: 10.1007/s11684-009-0079-5

Abstract: paper aims to evaluate the effects and the possible mechanisms of atorvastatin on tumor growth and metastasisAt the end of the experiment, the tumor volume and weight and the lung metastasis colonies of each mouseAtorvastatin suppressed xenograft tumor growth and metastasis both in the low-dose and the high-doseThis suggests that atorvastatin has the efficacy of suppressing tumor growth and metastasis .

Keywords： atorvastatin     xenograft tumor     metastasis     CYP2J2    

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Prognostic value of the 21-gene recurrence score in ER-positive, HER2-negative, node-positive breastcancer was similar in node-negative diseases: a single-center study of 800 patients

Jiayi Wu, Weiqi Gao, Xiaosong Chen, Chunxiao Fei, Lin Lin, Weiguo Chen, Ou Huang, Siji Zhu, Jianrong He, Yafen Li, Li Zhu, Kunwei Shen

Frontiers of Medicine 2021, Volume 15, Issue 4,   Pages 621-628 doi: 10.1007/s11684-020-0738-0

Abstract: Multi-gene assays have emerged as crucial tools for risk stratification in early-stage breast cancer. This study aimed to evaluate the prognostic significance of the 21-gene recurrence score (RS) in Chinese patients with pN0-1, estrogen receptor-positive (ER ), human epidermal growth factor receptor 2-negative (HER2 ) breast cancer. Among 800 patients recruited between 2009 and 2016, the median RS was 24 (0–69), with 27.4%, 46.8%, and 25.9% patients classified into low-, intermediate-, and high-risk groups. Cox regression analysis demonstrated that the high-risk category was associated with significantly higher odds of invasive disease-free survival (IDFS) and distant disease-free survival (DDFS) events compared with the low-risk category (IDFS: HR= 2.450, 95% CI 1.017–5.902, = 0.046; DDFS: HR= 2.829, 95% CI 1.013–7.901, = 0.047). No significant association between RS category and overall survival (OS) was found (intermediate vs. low: HR= 1.244, 95% CI 0.292–5.297, = 0.768; high vs. low: HR= 2.933, 95% CI 0.759–11.327, = 0.119). RS, as a continuous variable, was a highly significant predictor for IDFS (HR= 1.028, 95% CI 1.010–1.047, = 0.002), DDFS (HR= 1.030, 95% CI 1.010–1.051, = 0.003), and OS (HR= 1.034, 95% CI 1.007–1.063, = 0.014). Our findings suggested that RS may predict IDFS in Chinese patients with ER /HER2 breast cancer with N0 or N1 disease.

Keywords： early breast cancer     21-gene assay     recurrence score     prognosis    

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Study on road network model based on virtual node joint

Zhu Zhuangsheng,Wang Qing,Wan Dejun

Strategic Study of CAE 2009, Volume 11, Issue 8,   Pages 83-87

Abstract: text-align: justify;">The road network in the real world has been showed by the road network model based on nodeIt is the first time that a novel road network model,that is,the road network model based on virtual nodeThe novel model adops virtual node to show multi-road converging area,and the virtual node is an areaThe novel model has better of image the traffic flow on the road network than the old model based on node

Keywords： traffic engineering     virtual node     road network model     map matching     transportation planning    

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Overexpressed miR-9 promotes tumor metastasis via targeting E-cadherin in serous ovarian cancer

Bo Zhou, Hongbin Xu, Meng Xia, Chaoyang Sun, Na Li, Ensong Guo, Lili Guo, Wanying Shan, Hao Lu, Yifan Wu, Yuan Li, Degui Yang, Danhui Weng, Li Meng, Junbo Hu, Ding Ma, Gang Chen, Kezhen Li

Frontiers of Medicine 2017, Volume 11, Issue 2,   Pages 214-222 doi: 10.1007/s11684-017-0518-7

Abstract: Thus, our study demonstrates that miR-9 may promote ovarian cancer metastasis via targeting E-cadherinand a novel potential therapeutic approach to control metastasis of ovarian cancer.

Keywords： ovarian cancer     metastasis     miR-9     E-cadherin    

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Node Status Monitoring of Information-Centric Internet of Things

Cui Liqun, Wu Jun

Strategic Study of CAE 2020, Volume 22, Issue 6,   Pages 121-127 doi: 10.15302/J-SSCAE-2020.06.016

Abstract: network status information of the information-centric Internet of Things (IC-IoT), this study proposes a nodeIt first proposes a new management information base structure for recording various network node statusthe naming format of information-centric networking (ICN), centering on the content of the network node

Keywords： information-centric networking，Internet of Things，node status monitoring，access control    

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Epithelial-to-mesenchymal transition in cancer: complexity and opportunities

Yun Zhang, Robert A. Weinberg

Frontiers of Medicine 2018, Volume 12, Issue 4,   Pages 361-373 doi: 10.1007/s11684-018-0656-6

Abstract: drug-resistance and the ability to form metastases at distant organs, and thereby contribute to cancer metastasis

Keywords： epithelial-to-mesenchymal transition     cancer     metastasis     cancer stem cell    

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Title Author Date Type Operation

Application progress of lymphography in oncology

Yang YU, Jibin LIU, Lixue YIN

Journal Article

Correlation of Twist upregulation and senescence bypass during the progression and metastasis of cervical

Tian Wang, Yan Li, Abidan Tuerhanjiang, Wenwen Wang, Zhangying Wu, Ming Yuan, Shixuan Wang

Journal Article

Clinical significance of para-aortic lymph node dissection and prognosis in ovarian cancer

Xianxian Li, Hui Xing, Lin Li, Yanli Huang, Min Zhou, Qiong Liu, Xiaomin Qin, Min He

Journal Article

Adjuvant chemotherapy versus adjuvant concurrent chemoradiotherapy after radical surgery for early-stage cervical cancer: a randomized, non-inferiority, multicenter trial

Journal Article

The value of ultrasound elastography in differential diagnosis of superficial lymph nodes

Yanrong ZHANG phD , Qing LV MD , Mingxing XIE MD , Feixiang XIANG phD , Chengfa LU BM , Tianwei YAN BM , Wei LI BM , Hui XU BM , Yan HUANG BM , Yehua YIN BM ,

Journal Article

Superenhancers activate the autophagy-related genes Beclin1 and LC3B to drive metastasis and drug resistance

Journal Article

Osteopontin is a promoter for hepatocellular carcinoma metastasis: a summary of 10 years of studies

Lunxiu Qin

Journal Article

Bone metastasis of hepatocellular carcinoma: facts and hopes from clinical and translational perspectives

Journal Article

Spatial embedded reinforcement of 20-node block element for analysis PC bridges

LONG Peiheng, DU Xianting, CHEN Weizhen

Journal Article

Effect of atorvastatin on tumor growth and metastasis in a breast cancer cell xenograft model and its

Liu LIU MD, PhD, Yaogui NING MM, Chen CHEN MD, Daowen WANG MD, PhD,

Journal Article

Prognostic value of the 21-gene recurrence score in ER-positive, HER2-negative, node-positive breastcancer was similar in node-negative diseases: a single-center study of 800 patients

Jiayi Wu, Weiqi Gao, Xiaosong Chen, Chunxiao Fei, Lin Lin, Weiguo Chen, Ou Huang, Siji Zhu, Jianrong He, Yafen Li, Li Zhu, Kunwei Shen

Journal Article

Study on road network model based on virtual node joint

Zhu Zhuangsheng,Wang Qing,Wan Dejun

Journal Article

Overexpressed miR-9 promotes tumor metastasis via targeting E-cadherin in serous ovarian cancer

Bo Zhou, Hongbin Xu, Meng Xia, Chaoyang Sun, Na Li, Ensong Guo, Lili Guo, Wanying Shan, Hao Lu, Yifan Wu, Yuan Li, Degui Yang, Danhui Weng, Li Meng, Junbo Hu, Ding Ma, Gang Chen, Kezhen Li

Journal Article

Node Status Monitoring of Information-Centric Internet of Things

Cui Liqun, Wu Jun

Journal Article

Epithelial-to-mesenchymal transition in cancer: complexity and opportunities

Yun Zhang, Robert A. Weinberg

Journal Article